Analytical Data
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Gene name
AE-binding 蛋白 1/Aebp1
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简介
AE-binding protein 1/Aebp1 Protein, Mouse (His-SUMO) plays a critical role in regulating adipogenesis, and the proinflammation process in macrophages, including macrophage cholesterol homeostasis, foam cell formation and the development of atherosclerosis[1][2].
- Application
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Alternative Names
Aebp1; Aclp; Adipocyte enhancer-binding protein 1; AE-binding protein 1; Aortic carboxypeptidase-like protein
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Species
Mouse
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Source
E. coli
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Tag
his
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q640N1
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Expression Region
554-895aa
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AA Sequence
RHHSYKDMRQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQV
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Molecular Weight
39.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
AE-binding protein 1 (AEBP1) is a transcriptional regulator that plays a crucial role in various biological processes, including adipogenesis, inflammation, and the regulation of extracellular matrix components. This protein binds to specific DNA sequences and modulates gene expression, impacting cellular responses in diverse tissues. Studies have linked AEBP1 to metabolic disorders such as obesity and diabetes, highlighting its significance in energy homeostasis and lipid metabolism. Additionally, AEBP1 is implicated in the inflammatory response, suggesting its potential as a therapeutic target for chronic inflammatory diseases. Research into AEBP1 involves the development of recombinant protein variants, which allows for detailed analysis of its functional properties, interactions, and regulatory mechanisms. By utilizing recombinant technology, scientists can produce AEBP1 in sufficient quantities for functional assays, structural studies, and potential drug screening. The ongoing investigation of AEBP1's role in pathophysiological conditions holds promise for developing novel therapeutic strategies aimed at metabolic syndrome and inflammatory diseases, making it a focal point of current biomedical research.
