Analytical Data
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基因名
FBXL4
- Application
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别名
FBXL4; FBL4; FBL5F-box/LRR-repeat protein 4; F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKA2
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表达区间
1-621aa
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氨基酸序列
MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPNFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPTKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSLIDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFNHIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELNASFPKVFIKKSFTQ
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分子量
96.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXL4, a member of the F-box protein family, plays a critical role in the ubiquitin-proteasome pathway, which is essential for protein degradation and cellular regulation. The protein is particularly notable for its involvement in various cellular processes, including cell cycle regulation, signal transduction, and maintaining protein homeostasis. Mutations in the FBXL4 gene have been implicated in a range of diseases, such as developmental disorders and mitochondrial dysfunction, emphasizing its importance in human health. Research into FBXL4 recombinant proteins has gained momentum in recent years, as understanding its structure and function can provide insights into the molecular mechanisms of diseases associated with its dysregulation. Recombinant FBXL4 proteins can be utilized in various biochemical assays, facilitating the study of protein interactions, ubiquitination processes, and the identification of potential therapeutic targets. Moreover, the development of FBXL4-based biomolecular tools may lead to novel strategies for treating diseases linked to its dysfunction. As the scientific community explores the complexities of the ubiquitin-proteasome system, FBXL4 stands out as a promising candidate for further investigation, offering avenues to unravel the intricate networks that sustain cellular homeostasis and signal transduction. Consequently, the study of FBXL4 recombinant proteins serves not only as a means to deepen our understanding of fundamental biological processes but also as a potential stepping stone towards innovative therapeutic approaches to combat related diseases.
