Analytical Data
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Gene name
CDH23
- Application
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Alternative Names
CDH23；KIAA1774；KIAA1812；Cadherin-23
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H251
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDH23 (Cadherin 23) is a member of the cadherin superfamily, which plays a crucial role in cell adhesion and is primarily expressed in the sensory hair cells of the inner ear, as well as in the retina. Understanding the structure and function of CDH23 is essential for elucidating its role in hereditary hearing loss and other sensory disorders. Mutations in the CDH23 gene have been linked to non-syndromic hearing loss (DFNB12) and Usher syndrome type 1D, highlighting its importance in maintaining the mechanosensory function of hair cells. Research efforts have focused on producing recombinant CDH23 proteins to investigate their biochemical properties and interactions with other cellular components. By generating and purifying these recombinant proteins, scientists aim to analyze their structure through techniques such as X-ray crystallography or cryo-electron microscopy. Additionally, studying the binding affinities and functional mechanisms of CDH23 in in vitro models can provide insights into how disruptions in its function lead to sensory deficits. Overall, the recombinant CDH23 research not only enhances our understanding of auditory and visual systems but also paves the way for potential therapeutic interventions in genetic hearing loss and related conditions.
