Analytical Data
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基因名
LIFR
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简介
LIFR protein is an important member of the type I cytokine receptor family, mediating cellular responses to a variety of cytokines, emphasizing its role in cell differentiation and immune regulation. LIFR Protein, Rat (HEK293, His) is the recombinant rat-derived LIFR protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Leukemia inhibitory factor receptor; LIF-R; CD118
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种属
Rat
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
G3V7K2
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表达区间
L44-S829
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蛋白长度
Partial
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分子量
116 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
LIFR (Leukemia Inhibitory Factor Receptor) is a key component of the signaling pathway activated by leukemia inhibitory factor (LIF), a cytokine associated with various biological processes, including stem cell maintenance, differentiation, and inflammation. The role of LIFR in these processes has drawn significant interest in the fields of developmental biology and regenerative medicine. Moreover, LIFR has been implicated in several pathological conditions, including cancer and autoimmune diseases, making it a potential target for therapeutic interventions. Research has focused on the characterization of LIFR in both normal and diseased states, revealing its importance in cellular responses to LIF and its potential implications in cell signaling pathways that regulate cell fate. Furthermore, the recombinant expression of LIFR allows for detailed studies of its functional properties and interaction with other molecules. By producing LIFR in a controlled environment, researchers can explore the receptor’s structural characteristics, assess ligand-binding dynamics, and evaluate downstream signaling effects. Understanding LIFR's mechanism of action could lead to novel strategies for manipulating stem cell behavior and developing new treatments for diseases associated with dysregulated LIFR signaling. Thus, ongoing research into LIFR and its recombinant protein forms is crucial for advancing our knowledge of cell signaling and its applications in biotechnology and medicine.
