Analytical Data
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Gene name
NOTCH4
- Application
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Alternative Names
NOTCH4；INT3；Neurogenic locus notch homolog Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99466
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Notch4 is a member of the Notch family of receptors, which play a crucial role in cell communication and developmental processes, particularly in regulating cell fate decisions, differentiation, and proliferation. Dysregulation of Notch signaling has been implicated in various cancers and other diseases, making it a significant target for therapeutic intervention. The study of Notch4, specifically, has garnered attention due to its unique functions compared to other Notch receptors and its potential role in vascular biology and immune responses. Researchers have been interested in characterizing Notch4, particularly focusing on its structure, function, and the downstream signaling pathways it activates. The generation of recombinant Notch4 proteins has enabled scientists to investigate its molecular interactions and the resulting biological implications, providing insights into its role in both normal physiology and disease states. Understanding Notch4 signaling could pave the way for developing innovative treatments targeting Notch-related malignancies and vascular disorders.
