Analytical Data
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Gene name
SPINK6
- Application
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Alternative Names
Acrosin inhibitor; BUSI2; EG433180; ISK6_HUMAN; MGC21394; Protease inhibitor H; Serine protease inhibitor Kazal-type 6; Spink5l1; SPINK6; UNQ844; UNQ844/PRO1782
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UWN8
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Expression Region
24-80aa
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AA Sequence
QGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA FCKAIVKSGG KISLKHPGKC
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Molecular Weight
8.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SPINK6 (serine peptidase inhibitor, Kazal type 6) is a member of the Kazal-type serine protease inhibitor family, playing a crucial role in regulating proteolytic enzymes and maintaining homeostasis within various physiological systems. Recent studies have implicated SPINK6 in several pathological conditions, including inflammatory diseases and cancer, suggesting that it may be involved in modulating immune responses and tumorigenesis. Given its potential as a biomarker and therapeutic target, there has been a growing interest in characterizing SPINK6 at a molecular level. The production of recombinant SPINK6 protein enables detailed studies of its functional properties, interactions with serine proteases, and implications in disease mechanisms. Research has focused on understanding the structure-function relationship of SPINK6, investigating its inhibitory activity against specific proteases, and exploring its role in cellular signaling pathways. Additionally, recombinant SPINK6 provides a platform for evaluating its therapeutic potential, including its use in drug development and as a tool for understanding the proteolytic landscape in various diseases. Understanding SPINK6's biological functions and interactions will contribute significantly to the field of protease inhibition and disease treatment strategies.
