Analytical Data
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基因名
GRIA2
- Application
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别名
GRIA2；GluA2；GLUR2；Glutamate receptor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42262
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表达区间
25-543aa
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氨基酸序列
NSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA
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分子量
63.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRIA2, also known as Glutamate Receptor Ionotropic, Amplified 2, is a pivotal subunit of the AMPA receptor, which plays a crucial role in fast synaptic transmission in the central nervous system. As a key component of excitatory neurotransmission, GRIA2 is implicated in various physiological processes, including learning and memory. Dysregulation of GRIA2 has been associated with several neurological disorders, such as epilepsy, schizophrenia, and mood disorders. Research into GRIA2 recombinant proteins has garnered significant attention due to their potential for therapeutic applications and their utility in studying receptor functions and interactions. By producing GRIA2 recombinant proteins, scientists can investigate the receptor's structure, ligand-binding properties, and interaction with auxiliary proteins, offering insights into its physiological roles and pathological implications. Additionally, these recombinant proteins serve as valuable tools for screening pharmacological agents that may modulate GRIA2 activity, paving the way for novel strategies in treating conditions linked to excitatory neurotransmission dysfunction. The ongoing exploration of GRIA2 recombinant proteins holds promise for advancing our understanding of synaptic mechanisms and developing targeted interventions for related neurological disorders.
