Analytical Data
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基因名
CUL5
- Application
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别名
CUL-5;Vasopressin-activated calcium-mobilizing receptor 1;VACM-1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q93034
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表达区间
1-780aa
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氨基酸序列
MATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA
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分子量
97.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CUL5 (Cullin 5) is a member of the Cullin family of proteins that play a crucial role in the ubiquitin-proteasome system, which is responsible for the regulated degradation of proteins within the cell. As a key component of E3 ubiquitin ligase complexes, CUL5 facilitates the ubiquitination of target substrates, thereby influencing various cellular processes such as signal transduction, cell cycle regulation, and immune responses. Recent research has highlighted CUL5's involvement in various pathological conditions, including cancer, viral infections, and autoimmune diseases. Notably, CUL5 has been implicated in the regulation of viral proteins, particularly in the context of HIV and other retroviruses, where it aids in the degradation of host proteins that inhibit viral replication. The characterization of CUL5 and its interactions at the molecular level has opened avenues for therapeutic interventions targeting the ubiquitin-proteasome pathway. Understanding CUL5's structural properties and functional mechanisms is essential for developing novel strategies to manipulate its activity in disease contexts. Furthermore, CUL5's potential as a biomarker for certain diseases underscores the importance of ongoing research into its biological functions and regulatory mechanisms. As such, creating recombinant forms of CUL5 for study can significantly advance our understanding of its physiological roles and therapeutic potential in diverse diseases.
