Analytical Data
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Gene name
SERF1A
- Application
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Alternative Names
SERF1A; FAM2A; SERF1; SMAM1;; SERF1B; FAM2B; SERF1; SMAM1; Small EDRK-rich factor 1; Protein 4F5; h4F5; SMA modifier 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75920
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Expression Region
1-110 aa
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AA Sequence
MARGNQRELA RQKNMKKTQE ISKGKRKEDS LTASQRKQSS GGQKSESKMS AGPHLPLKAP RENPCFPLPA AGGSRYYLAY GSITPISAFV FVVFFSVFFP SFYEDFCCWI
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Molecular Weight
12.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SERF1A (Small EDRK-rich Factor 1A) is a protein that plays a critical role in various cellular processes, including protein folding, stress response, and cellular differentiation. It has recently gained attention due to its potential involvement in neurodegenerative diseases and cancer. Research indicates that SERF1A interacts with molecular chaperones, enhancing their stability and function, which is crucial in maintaining proteostasis within cells. Furthermore, studies have revealed that SERF1A may modulate the activity of key proteins involved in signaling pathways, contributing to cell survival and apoptosis. Given its multifaceted roles, understanding the molecular mechanisms underlying SERF1A's function is essential for unraveling its impact on disease processes. The recombinant expression of SERF1A in vitro allows for detailed characterization of its structural properties and functional assays, facilitating the identification of potential therapeutic targets. Additionally, exploring SERF1A's interactions with other cellular components may provide insights into its regulatory mechanisms and implications in health and disease, paving the way for novel treatments in conditions where SERF1A is dysregulated. As such, ongoing research into SERF1A serves not only to elucidate its biological significance but also to establish its potential as a biomarker or target for therapeutic intervention in disorders associated with its dysfunction.
