Analytical Data
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Gene name
RNF38
- Application
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Alternative Names
RING finger protein 38; Rnf38; RNF38_HUMAN; RP11-84P7.4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0F5
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Expression Region
1-515 aa
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AA Sequence
MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK AFFQSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV CSVPPPMLQA CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP AVGPTFSFEL DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP CNHEFHAKCV DKWLKANRTC PICRADASEV HRDSE
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Molecular Weight
57.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF38 (RING finger protein 38) is a member of the RING finger family of E3 ubiquitin ligases, known for its critical role in regulating protein degradation and various cellular processes through ubiquitination. Research into RNF38 has gained momentum due to its implications in cancer biology and cellular stress responses. Recent studies have highlighted its involvement in modulating key signaling pathways, influencing cell proliferation, apoptosis, and DNA damage response. Furthermore, aberrations in RNF38 expression or function have been linked to various malignancies, suggesting a potential role in tumorigenesis and cancer progression. The recombinant protein of RNF38 is of significant interest for understanding its structure-function relationships and molecular mechanisms. By producing RNF38 in a recombinant form, researchers can investigate its biochemical properties, interactions with substrate proteins, and its influence on the ubiquitin-proteasome system. This research is not only important for elucidating the fundamental biology of RNF38 itself but also holds promise for developing novel therapeutic strategies targeting E3 ligases in cancer treatment. Overall, the study of RNF38 recombinant protein serves as a crucial step in uncovering its biological roles and therapeutic potential.
