Analytical Data
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基因名
OSTM1
- Application
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别名
OSTM1；GL；Osteopetrosis-associated transmembrane Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86WC4
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表达区间
1-284aa
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氨基酸序列
MEPGPTAAQR RCSLPPWLPL GLLLWSGLAL GALPFGSSPH RVFHDLLSEQ QLLEVEDLSL SLLQGGGLGP LSLPPDLPDL DPECRELLLD FANSSAELTG CLVRSARPVR LCQTCYPLFQ QVVSKMDNIS RAAGNTSESQ SCARSLLMAD RMQIVVILSE FFNTTWQEAN CANCLTNNSE ELSNSTVYFL NLFNHTLTCF EHNLQGNAHS LLQTKNYSEV CKNCREAYKT LSSLYSEMQK MNELENKAEP GTHLCIDVED AMNITRKLWS RTFNCSVPCS DTVP
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分子量
30 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OSTM1 (OST-48, hOST-48, or Oligosaccharyltransferase Subunit 1) is a critical protein involved in the N-glycosylation process, which plays a vital role in protein folding, stability, and function. Research into OSTM1 has gained momentum due to its implications in various cellular processes and diseases, including its potential role in cancer progression and autoimmune disorders. OSTM1 is part of the oligosaccharyltransferase complex responsible for transferring oligosaccharides to nascent proteins in the endoplasmic reticulum (ER). Proper glycosylation is essential for protein maturation and function, and any dysregulation can lead to pathological conditions. Investigating the structure, function, and regulation of OSTM1 not only enhances our understanding of glycosylation but also provides insights into therapeutic strategies for diseases associated with glycosylation defects. Advances in recombinant protein technology have enabled the expression and purification of OSTM1, facilitating detailed studies of its biochemical properties and interactions with other cellular components. This research is crucial for elucidating the mechanisms by which OSTM1 contributes to cellular homeostasis and identifying potential molecular targets for drug development, offering promising avenues for innovative treatments in the context of glycosylation-related disorders.
