Cat: PA1000-5997

Recombinant Human STXBP3 Protein,His

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Analytical Data

  • Gene name

    STXBP3

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    STXBP3;Syntaxin-binding Protein 3

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O00186

  • Expression Region

    1-592aa

  • AA Sequence

    MAPPVAERGL KSVVWQKIKA TVFDDCKKEG EWKIMLLDEF TTKLLASCCK MTDLLEEGIT VVENIYKNRE PVRQMKALYF ITPTSKSVDC FLHDFASKSE NKYKAAYIYF TDFCPDNLFN KIKASCSKSI RRCKEINISF IPHESQVYTL DVPDAFYYCY SPDPGNAKGK DAIMETMADQ IVTVCATLDE NPGVRYKSKP LDNASKLAQL VEKKLEDYYK IDEKSLIKGK THSQLLIIDR GFDPVSTVLH ELTFQAMAYD LLPIENDTYK YKTDGKEKEA ILEEEDDLWV RIRHRHIAVV LEEIPKLMKE ISSTKKATEG KTSLSALTQL MKKMPHFRKQ ITKQVVHLNL AEDCMNKFKL NIEKLCKTEQ DLALGTDAEG QKVKDSMRVL LPVLLNKNHD NCDKIRAILL YIFSINGTTE ENLDRLIQNV KIENESDMIR NWSYLGVPIV PQSQQGKPLR KDRSAEETFQ LSRWTPFIKD IMEDAIDNRL DSKEWPYCSQ CPAVWNGSGA VSARQKPRAN YLEDRKNGSK LIVFVIGGIT YSEVRCAYEV SQAHKSCEVI IGSTHVLTPK KLLDDIKMLN KPKDKVSLIK DE

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

Related Products

Protein Description

STXBP3, or Syntaxin Binding Protein 3, is a member of the Sec1/Munc18 (SM) protein family, playing a crucial role in vesicle trafficking and membrane fusion processes essential for neurotransmitter release. Research on STXBP3 has garnered interest due to its implications in neurological disorders, particularly its potential involvement in synaptic function and plasticity. Abnormalities in STXBP3 expression and function have been linked to conditions such as autism spectrum disorders and schizophrenia, highlighting its significance in the central nervous system. Studies have shown that STXBP3 interacts with various SNARE proteins, modulating the assembly of the SNARE complex necessary for exocytosis. Understanding the structure and function of recombinant STXBP3 protein is vital for elucidating its role in synaptic transmission. The production of recombinant STXBP3 enables in-depth biochemical and biophysical studies, facilitating the exploration of its interaction with other proteins and its participation in neurotransmitter release pathways. Investigating STXBP3 not only provides insights into fundamental cellular mechanisms but also suggests potential therapeutic targets for treating neurological diseases where synaptic dysfunction is a hallmark. Overall, the study of STXBP3 recombinant protein is crucial for advancing our understanding of synaptic biology and the molecular underpinnings of related disorders.

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