Analytical Data
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Gene name
RNF141
- Application
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Alternative Names
RNF141; ZNF230; RING finger protein 141; Zinc finger protein 230
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WVD5
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Expression Region
1-230 aa
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AA Sequence
MGQQISDQTQ LVINKLPEKV AKHVTLVRES GSLTYEEFLG RVAELNDVTA KVASGQEKHL LFEVQPGSDS SAFWKVVVRV VCTKINKSSG IVEASRIMNL YQFIQLYKDI TSQAAGVLAQ SSTSEEPDEN SSSVTSCQAS LWMGRVKQLT DEEECCICMD GRADLILPCA HSFCQKCIDK WSDRHRNCPI CRLQMTGANE SWVVSDAPTE DDMANYILNM ADEAGQPHRP
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Molecular Weight
25.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF141 is a member of the RING-type E3 ubiquitin ligase family, which plays a crucial role in regulating various cellular processes, including protein degradation, cell cycle progression, and signal transduction. Its involvement in the ubiquitin-proteasome system highlights the importance of protein modification in maintaining cellular homeostasis and responding to stress. Recent studies have shown that RNF141 may contribute to the development of various cancers, as it can influence tumor suppressor proteins and oncogenic pathways. Given its potential implications in cancer biology and other diseases, researching RNF141 recombinant protein is essential to elucidate its structure-function relationship and regulatory mechanisms. Understanding RNF141's role could unveil new therapeutic targets and strategies. By producing and characterizing recombinant RNF141, researchers aim to explore its biochemical activities, interaction partners, and potential as a biomarker or therapeutic target in cancer and other pathologies, making it a significant focus in molecular biology and drug discovery.
