Analytical Data
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基因名
CACNB1
- Application
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别名
CAB1; CACB1_HUMAN; CACNB1; CACNLB1; Calcium channel L type beta 1 polypeptide; Calcium channel voltage dependent beta 1 subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02641
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表达区间
1-598aa
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氨基酸序列
MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR LGSSKSGDNS SSSLGDVVTG TRRPTPPASA KQKQKSTEHV PPYDVVPSMR PIILVGPSLK GYEVTDMMQK ALFDFLKHRF DGRISITRVT ADISLAKRSV LNNPSKHIII ERSNTRSSLA EVQSEIERIF ELARTLQLVA LDADTINHPA QLSKTSLAPI IVYIKITSPK VLQRLIKSRG KSQSKHLNVQ IAASEKLAQC PPEMFDIILD ENQLEDACEH LAEYLEAYWK ATHPPSSTPP NPLLNRTMAT AALAASPAPV SNLQGPYLAS GDQPLERATG EHASMHEYPG ELGQPPGLYP SSHPPGRAGT LRALSRQDTF DADTPGSRNS AYTELGDSCV DMETDPSEGP GLGDPAGGGT PPARQGSWED EEEDYEEELT DNRNRGRNKA RYCAEGGGPV LGRNKNELEG WGRGVYIR
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分子量
65.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CACNB1, a gene encoding the beta-1 subunit of voltage-gated calcium channels, plays a crucial role in calcium ion influx, which is essential for various physiological processes including muscle contraction, neurotransmitter release, and cardiac function. Recent research has highlighted the importance of CACNB1 in the pathogenesis of multiple diseases, including psychiatric disorders and cardiac anomalies. Mutations and dysregulation of this gene have been implicated in conditions like Timothy Syndrome and other channelopathies, which have significant clinical implications. The recombinant protein of CACNB1 is thus a focus of interest for researchers aiming to better understand its structure-function relationship and the mechanisms by which it contributes to cellular signaling. Studying the recombinant protein allows for in-depth investigation of its interaction with other channel subunits and regulatory proteins, enhancing our understanding of calcium channel function and its role in disease states. Moreover, the recombinant CACNB1 protein serves as a potential target for drug development, aiming to design therapeutics that can correct the dysfunctions associated with altered calcium signaling. Overall, ongoing research involving CACNB1 recombinant protein can provide insights into fundamental calcium channel physiology and pave the way for novel therapeutic strategies in diseases linked to calcium signaling dysregulation.
