Analytical Data
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Gene name
RABL3
- Application
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Alternative Names
RAB member of RAS oncogene family like 3; Rab-like protein 3; RABL3; RABL3_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5HYI8
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Expression Region
1-236 aa
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AA Sequence
MASLDRVKVL VLGDSGVGKS SLVHLLCQNQ VLGNPSWTVG CSVDVRVHDY KEGTPEEKTY YIELWDVGGS VGSASSVKST RAVFYNSVNG IIFVHDLTNK KSSQNLRRWS LEALNRDLVP TGVLVTNGDY DQEQFADNQI PLLVIGTKLD QIHETKRHEV LTRTAFLAED FNPEEINLDC TNPRYLAAGS SNAVKLSRFF DKVIEKRYFL REGNQIPGFP DRKRFGAGTL KSLHYD
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Molecular Weight
26.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RABL3, a member of the RAS superfamily of GTPases, has emerged as a significant protein in the study of cell signaling and intracellular trafficking. Initially thought to be involved primarily in the regulation of the cytoskeleton and membrane dynamics, recent research highlights its role in various cellular processes, including cell morphogenesis and migration. RABL3 is mainly localized to cilia, suggesting its potential involvement in signaling pathways related to development and disease, particularly in cancer and ciliopathies. Its peculiar structure allows for interactions with other signaling proteins, which may influence pathways such as the mTOR pathway and Hedgehog signaling. Given the increasing evidence linking dysregulation of RABL3 to various pathologies, understanding its function through the study of recombinant RABL3 protein has gained momentum. Researchers are exploring the biochemical properties of this GTPase, investigating its nucleotide-binding capacity and GTPase activity, as well as its interactions with downstream effectors. The generation of recombinant RABL3 offers a unique opportunity to elucidate its role within the cellular context and to assess its potential as a therapeutic target. By employing various biochemical and biophysical techniques, studies aim to unravel the intricate mechanisms governed by RABL3 and its implications in health and disease, thereby contributing to the broader understanding of RAS-related signaling pathways. This line of inquiry may pave the way for innovative strategies in the treatment of diseases where RABL3 signaling is altered.
