Analytical Data
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Gene name
RABGGTB
- Application
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Alternative Names
RABGGTB; GGTB; Geranylgeranyl transferase type-2 subunit beta; EC 2.5.1.60; Geranylgeranyl transferase type II subunit beta; GGTase-II-beta; Rab geranyl-geranyltransferase subunit beta; Rab GG transferase beta; Rab GGTase beta; Rab geranylgeranyltransferase subunit beta; Type II protein geranyl-geranyltransferase subunit beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P53611
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Expression Region
2-331 aa
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AA Sequence
GTPQKDVII KSDAPDTLLL EKHADYIASY GSKKDDYEYC MSEYLRMSGI YWGLTVMDLM GQLHRMNREE ILAFIKSCQH ECGGISASIG HDPHLLYTLS AVQILTLYDS INVIDVNKVV EYVKGLQKED GSFAGDIWGE IDTRFSFCAV ATLALLGKLD AINVEKAIEF VLSCMNFDGG FGCRPGSESH AGQIYCCTGF LAITSQLHQV NSDLLGWWLC ERQLPSGGLN GRPEKLPDVC YSWWVLASLK IIGRLHWIDR EKLRNFILAC QDEETGGFAD RPGDMVDPFH TLFGIAGLSL LGEEQIKPVN PVFCMPEEVL QRVNVQPELV S
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Molecular Weight
36.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RABGGTB, or Rab geranylgeranyl transferase beta, is an enzyme that plays a crucial role in the post-translational modification of Rab proteins, which are essential regulators of intracellular trafficking. These proteins are involved in various cellular processes, including vesicle transport, membrane fusion, and signal transduction. The proper functioning of Rab proteins is critical for maintaining cellular homeostasis, and aberrations in their geranylgeranylation can lead to various pathologies, including cancer and neurodegenerative disorders. Research on RABGGTB has gained momentum as scientists aim to better understand its biochemical mechanisms and regulatory pathways, which could uncover potential therapeutic targets. The study of RABGGTB also involves exploring its interactions with other cellular proteins and its role in the broader context of Rab protein networks. This research has important implications for developing strategies to manipulate Rab protein function in disease contexts, thereby opening avenues for targeted therapies. Additionally, advancements in biotechnology and molecular biology techniques have enabled researchers to explore recombinant expression systems for RABGGTB, facilitating detailed structural and functional analyses. Overall, the investigation into RABGGTB is an exciting frontier in cellular and molecular biology, with the potential to impact diverse fields such as drug development and gene therapy.
