Analytical Data
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Gene name
PDGF-CC
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简介
Platelet derived growth factor C (PDGF-CC) is a growth factor that plays an essential role in the regulation of cell proliferation, cell migration, survival and chemotaxis. PDGF-CC is a potent mitogen and chemoattractant for cells of mesenchymal origin which plays an important roll in normal skeleton formation and normal skin morphogenesis during embryonic development, wound healing, angiogenesis and blood vessel development as well as being involved in fibrotic processes. PDGF-CC Protein, Cynomolgus (HEK293, hFc) is the recombinant cynomolgus-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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Biological Activity
Measured in a cell proliferation assay using NIH/3T3 cells. The ED50 for this effect is 15.09 ng/mL, corresponding to a specific activity is 66269.052 units/mg. Measured in a cell proliferation assay using NIH/3T3 cells. The ED50 for this effect is 15.09 ng/mL, corresponding to a specific activity is 66269.052 units/mg.
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Alternative Names
PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF
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Species
Cynomolgus
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Uniprot
EHH54037
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Expression Region
V196-G306
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Protein Length
Partial
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Molecular Weight
45-50 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Platelet-Derived Growth Factor CC (PDGF-CC) is a member of the PDGF family, which plays a crucial role in various biological processes, including cell proliferation, survival, and migration. PDGF-CC has garnered significant research interest due to its distinct structural properties and its involvement in several pathological conditions, such as fibrosis, cancer, and vascular diseases. Unlike other PDGF isoforms, PDGF-CC is uniquely characterized by its ability to activate the PDGF receptor through dimerization, leading to the stimulation of downstream signaling pathways. Research has shown that PDGF-CC is upregulated in response to tissue injury and contributes to the pathological remodeling of tissues, making it a potential therapeutic target for conditions involving abnormal tissue repair and inflammation. Recombinant PDGF-CC has been developed to further understand its biological functions and therapeutic possibilities. Studies are ongoing to elucidate the molecular mechanisms governing PDGF-CC signaling and its role in disease processes, highlighting its potential applications in regenerative medicine and targeted therapies. Overall, the investigation of PDGF-CC not only contributes to the fundamental understanding of growth factor biology but also opens avenues for novel treatment strategies in various diseases characterized by dysregulated cell and tissue dynamics.
