Analytical Data
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Gene name
PDGF-CC
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简介
The PDGF-CC protein is a key growth factor that plays crucial roles in a variety of cellular processes, including embryonic development, cell proliferation, migration, survival, and chemotaxis. It has potent mitogenic and chemoattractant properties and is essential during embryonic skeletal formation, craniofacial development, palate development, skin morphogenesis and wound healing stages. PDGF-CC Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PDGF-CC protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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Biological Activity
Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblasts cells. The ED50 this effect is 61.4 ng/mL, corresponding to a specific activity is 1.6287×10^4 units/mg. Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblasts cells. The ED50 for this effect is 61.4 ng/mL, corresponding to a specific activity is 1.6287×104 units/mg.
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Alternative Names
PDGF-C; Platelet derived growth factor C; VEGF-E; SCDGF
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Species
Mouse
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 95% as determined by reducing SDS-PAGE
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Uniprot
Q8CI19
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Expression Region
V235-G345
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Protein Length
Partial
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Molecular Weight
46 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Platelet-Derived Growth Factor CC (PDGF-CC) is a member of the PDGF family, which plays a crucial role in various biological processes, including cell proliferation, survival, and migration. PDGF-CC has garnered significant research interest due to its distinct structural properties and its involvement in several pathological conditions, such as fibrosis, cancer, and vascular diseases. Unlike other PDGF isoforms, PDGF-CC is uniquely characterized by its ability to activate the PDGF receptor through dimerization, leading to the stimulation of downstream signaling pathways. Research has shown that PDGF-CC is upregulated in response to tissue injury and contributes to the pathological remodeling of tissues, making it a potential therapeutic target for conditions involving abnormal tissue repair and inflammation. Recombinant PDGF-CC has been developed to further understand its biological functions and therapeutic possibilities. Studies are ongoing to elucidate the molecular mechanisms governing PDGF-CC signaling and its role in disease processes, highlighting its potential applications in regenerative medicine and targeted therapies. Overall, the investigation of PDGF-CC not only contributes to the fundamental understanding of growth factor biology but also opens avenues for novel treatment strategies in various diseases characterized by dysregulated cell and tissue dynamics.
