Analytical Data
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基因名
TEX12
- Application
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别名
TEX12；Testis-expressed Protein 12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXU0
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表达区间
1-123aa
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氨基酸序列
MMANHLVKPDNRNCKRPRELESPVPDSPQLSSLGKSDSSFSEISGLFYKDEALEKDLNDVSKEINLMLSTYAKLLSERAAVDASYIDEIDELFKEANAIENFLIQKREFLRQRFTVIANTLHR
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分子量
41.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The TEX12 protein, part of the telomerase complex, has gained significant attention due to its potential implications in cancer biology and reproductive health. Telomerase, an enzyme responsible for extending telomeres, plays a crucial role in cellular aging and immortality, especially in stem cells and cancer cells. TEX12 is a testis-specific protein implicated in the regulation of telomerase activity during spermatogenesis. Its dysregulation has been linked to various reproductive disorders and oncogenic processes. Research on TEX12 has revealed that it may serve as a novel biomarker for testicular cancer and other tumors, providing insights into tumorigenesis mechanisms. Additionally, the protein's specific expression in germ cells highlights its potential utility as a target for male contraceptive development. Understanding the structure and function of TEX12 is essential for elucidating its role in telomere maintenance, cell cycle regulation, and possibly the broader implications of telomerase in human health. Ongoing studies aim to characterise the protein's interactions within the telomerase complex and its regulatory networks, thereby paving the way for future therapeutic strategies targeting TEX12-related pathways in cancer and infertility.
