Analytical Data
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Gene name
BAMBI
- Application
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Alternative Names
BAMBI；NMA；BMP and activin membrane-bound inhibitor homolog
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13145
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Expression Region
1-152aa
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AA Sequence
MDRHSSYIFI WLQLELCAMA VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RA
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Molecular Weight
16 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BAMBI (Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor) is a crucial regulator in the TGF-β superfamily signaling pathways, specifically modulating the activities of bone morphogenetic proteins (BMPs) and activins. Research into BAMBI has gained significant attention due to its role in various biological processes, including embryonic development, tissue homeostasis, and the regulation of stem cell differentiation. The expression of BAMBI is often upregulated in response to inflammatory stimuli and in various cancers, suggesting its involvement in tumor progression and the tumor microenvironment. Understanding BAMBI's function and mechanism of action can provide insights into its potential as a therapeutic target for diseases associated with dysregulated TGF-β signaling, including fibrosis and cancer. Researchers have focused on characterizing BAMBI interactions at the molecular level, exploring its effects on cellular signaling pathways and identifying possible pathways for intervention. By elucidating these mechanisms, studies aim to develop novel strategies to manipulate BAMBI activity, thereby enhancing tissue regeneration or inhibiting tumorigenesis. The increasing interest in BAMBI also reflects a broader trend in biomedical research emphasizing the importance of modulating the TGF-β superfamily for therapeutic benefits.
