Analytical Data
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Gene name
Gastrin-71/GAST
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简介
Gastrin-71/GAST proteins play key roles in regulating various physiological processes. It acts as a powerful stimulant, prompting the production and secretion of hydrochloric acid from the gastric mucosa and inducing the release of digestive enzymes from the pancreas. Gastrin-71/GAST Protein, Human (HEK293, Fc) is the recombinant human-derived Gastrin-71/GAST protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Gastrin-71/GAST Protein, Human (HEK293, Fc) is 71 a.a., with molecular weight of 33-35 kDa.
- Application
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Alternative Names
Gastrin-71; Gastrin; GAST; Gastrin component
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01350
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Expression Region
S22-F92
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Protein Length
Partial
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Molecular Weight
33-35 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Gastrin-71, also known as GAST, is a critical peptide hormone produced primarily by G cells in the stomach, playing a vital role in stimulating gastric acid secretion and promoting gastric motility. Its structure features a 71 amino acid length, with post-translational modifications that enhance its biological activity. Research on Gastrin-71 has garnered attention due to its implications in various gastrointestinal disorders, including gastritis, peptic ulcers, and gastric cancer. Elevated levels of Gastrin-71 are often observed in patients with these conditions, suggesting a potential role as a biomarker for disease states. Moreover, the overexpression of gastrin has been implicated in the proliferation of gastric cancer cells, emphasizing its importance in oncological studies. The recombinant production of Gastrin-71 protein facilitates advanced studies into its functional properties and therapeutic potential. This recombinant protein can be utilized in drug development, diagnostics, and the exploration of gastrin receptor signaling pathways. Understanding the molecular mechanisms underlying Gastrin-71's actions could lead to novel therapeutic strategies to manage gastric disorders, making it an important focus in both clinical and basic research.
