Analytical Data
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Gene name
EphA8
- Application
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Alternative Names
EphA8；EEK；Ephrin type-A receptor 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29322
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Expression Region
565-1005aa
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AA Sequence
KRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESLRATATVSRCPPPAFVRSCFDLRGGSGGGGGLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRALGITLMGHQKKILGSIQTMRAQLTSTQGPRRHL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA8, a member of the ephrin receptor family, plays a significant role in cell signaling, particularly in developmental processes and neural guidance. As a receptor tyrosine kinase, EphA8 is involved in various cellular functions, including cell adhesion, migration, and communication, making it crucial in the formation of neural networks and tissue architecture. Dysregulation of EphA8 signaling has been implicated in several pathological conditions, including cancer metastasis and neurodegenerative diseases. Hence, understanding the structure and function of EphA8 is vital for unraveling its contributions to health and disease. Researchers have focused on the development of recombinant EphA8 proteins to study its signaling pathways, ligand interactions, and receptor activation mechanisms in detail. These recombinant proteins serve as essential tools for deciphering the underlying molecular mechanisms of EphA8 in cell biology and for evaluating its potential as a therapeutic target. By generating and characterizing these proteins, the scientific community aims to provide insights into how EphA8 contributes to cellular processes and could offer novel approaches for intervention in diseases associated with its dysfunction.
