Analytical Data
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Gene name
BHLHB2
- Application
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Alternative Names
BHE40_HUMAN; bHLHB2; bHLHe40; Class B Basic Helix Loop Helix Protein 2; Class B basic helix-loop-helix Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14503
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Expression Region
1-412aa
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AA Sequence
MERIPSAQPP PACLPKAPGL EHGDLPGMYP AHMYQVYKSR RGIKRSEDSK ETYKLPHRLI EKKRRDRINE CIAQLKDLLP EHLKLTTLGH LEKAVVLELT LKHVKALTNL IDQQQQKIIA LQSGLQAGEL SGRNVETGQE MFCSGFQTCA REVLQYLAKH ENTRDLKSSQ LVTHLHRVVS ELLQGGTSRK PSDPAPKVMD FKEKPSSPAK GSEGPGKNCV PVIQRTFAHS SGEQSGSDTD TDSGYGGESE KGDLRSEQPC FKSDHGRRFT MGERIGAIKQ ESEEPPTKKN RMQLSDDEGH FTSSDLISSP FLGPHPHQPP FCLPFYLIPP SATAYLPMLE KCWYPTSVPV LYPGLNASAA ALSSFMNPDK ISAPLLMPQR LPSPLPAHPS VDSSVLLQAL KPIPPLNLET KD
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Molecular Weight
45.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BHLHB2, a member of the basic helix-loop-helix (bHLH) family of transcription factors, plays a crucial role in various biological processes, including cellular differentiation, proliferation, and apoptosis. Its expression is tightly regulated during development and in response to environmental cues, implicating its potential role in pathological conditions such as cancer and neurodegenerative diseases. Recent studies have suggested that BHLHB2 can modulate key signaling pathways by interacting with other transcription factors and regulatory proteins, thus influencing gene expression networks. Given its significance in gene regulation, the recombinant production of BHLHB2 protein presents an opportunity to explore its functional mechanisms and therapeutic potential. By employing techniques such as recombinant DNA technology, researchers aim to produce BHLHB2 in significant quantities for biochemical characterization, structural studies, and functional assays. Understanding the structure-function relationship of BHLHB2 can provide insights into its role in cellular contexts and disease states, enabling the development of targeted therapeutic strategies. The study of BHLHB2 and its recombinant protein is essential for deciphering its contributions to both fundamental biology and applied biomedical research.
