Analytical Data
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基因名
IL10RB
- Application
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别名
IL10RB；CRFB4；Interleukin-10 receptor subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08334
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表达区间
20-220aa
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氨基酸序列
MVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNT TLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQ VEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQI TPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVP SVDHHHHHH
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分子量
25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-10 receptor beta (IL10RB) is a crucial component of the interleukin-10 (IL-10) signaling pathway, which plays a significant role in regulating immune responses and maintaining homeostasis. Research has shown that IL-10, through its receptor complex involving IL10RB, exerts anti-inflammatory effects, making it an important target for therapeutic interventions in autoimmune diseases and chronic inflammatory conditions. Studies have indicated that variations or mutations in the IL10RB gene can be associated with susceptibility to various diseases, including systemic lupus erythematosus and inflammatory bowel disease. The recombinant protein of IL10RB allows researchers to explore its function, interactions with other signaling molecules, and its role in immune modulation in a controlled environment. By generating IL10RB as a recombinant protein, scientists can investigate its potential for therapeutic applications, including the development of targeted biologics that could restore IL-10 signaling in conditions where it is disrupted. Furthermore, understanding the structural and functional properties of IL10RB can provide insights into its role in receptor heterodimer formation and downstream signaling pathways, thereby contributing to the wider understanding of cytokine signaling and its implications in disease pathology. Overall, IL10RB recombinant protein research holds promise for advancing therapeutic strategies against immune-mediated diseases and enhancing our understanding of immune regulation mechanisms.
