Analytical Data
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Gene name
HACL1
- Application
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Alternative Names
HACL1；HPCL；HPCL2；PHYH2；2-hydroxyacyl-CoA lyase 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJ83
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Expression Region
1-578aa
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AA Sequence
MPDSNFAERS EEQVSGAKVI AQALKTQDVE YIFGIVGIPV TEIAIAAQQL GIKYIGMRNE QAACYAASAI GYLTSRPGVC LVVSGPGLIH ALGGMANANM NCWPLLVIGG SSERNQETMG AFQEFPQVEA CRLYTKFSAR PSSIEAIPFV IEKAVRSSIY GRPGACYVDI PADFVNLQVN VNSIKYMERC MSPPISMAET SAVCTAASVI RNAKQPLLII GKGAAYAHAE ESIKKLVEQY KLPFLPTPMG KGVVPDNHPY CVGAARSRAL QFADVIVLFG ARLNWILHFG LPPRYQPDVK FIQVDICAEE LGNNVKPAVT LLGNIHAVTK QLLEELDKTP WQYPPESKWW KTLREKMKSN EAASKELASK KSLPMNYYTV FYHVQEQLPR DCFVVSEGAN TMDIGRTVLQ NYLPRHRLDA GTFGTMGVGL GFAIAAAVVA KDRSPGQWII CVEGDSAFGF SGMEVETICR YNLPIILLVV NNNGIYQGFD TDTWKEMLKF QDATAVVPPM CLLPNSHYEQ VMTAFGGKGY FVQTPEELQK SLRQSLADTT KPSLINIMIE PQATRKAQDF HWLTRSNM
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Molecular Weight
63.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HACL1, or H(2)A deacetylase, is an enzyme that plays a crucial role in various physiological processes, including lipid metabolism and mitochondrial function. Its significance has garnered attention in recent years, particularly in the context of metabolic disorders, where dysregulation of lipid homeostasis is linked to conditions such as obesity, diabetes, and cardiovascular diseases. Research into recombinant HACL1 protein has emerged as a promising avenue to better understand its functional mechanisms and potential therapeutic applications. The recombinant expression of HACL1 allows for detailed studies of its enzymatic properties and interactions with other cellular pathways. Furthermore, elucidating the crystal structure of HACL1 can provide insights into its catalytic mechanisms and substrate specificity, which are vital for drug design aimed at modulating its activity. As scientists continue to explore the multifaceted roles of HACL1, understanding its molecular functions and regulatory networks may unlock new strategies for treating metabolic diseases and enhancing overall health.
