Analytical Data
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基因名
SNTA1
- Application
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别名
SNTA1;SNT1;Alpha-1-syntrophin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13424
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表达区间
1-505aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMASGRRAPRTGLLELRAGAGSGAGGER WQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQL PEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTE ALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFK NSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCT PNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKD ELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSL PETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVD THLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHI DKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQL DLHSCPKTIVFIIHSFLSAKVTRLGLLA
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分子量
56 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNTA1, or Syntrophin Alpha 1, is a member of the syntrophin family of proteins, which are crucial for the proper functioning of dystrophin-associated protein complexes in muscle and neuronal tissues. These complexes play a vital role in maintaining cellular membrane integrity, facilitating signal transduction, and anchoring ion channels and receptors. Research surrounding SNTA1 has gained significance due to its involvement in various pathophysiological conditions, such as muscular dystrophies and neurodegenerative diseases. Studies have suggested that dysregulation or mutations in SNTA1 can lead to impaired muscle function and contribute to the progression of disorders like Duchenne muscular dystrophy. Moreover, SNTA1 is implicated in cellular processes beyond muscle, including its interactions with several signaling pathways and potential roles in neurotransmitter release. The exploration of SNTA1 as a therapeutic target has led to an increased interest in developing recombinant SNTA1 proteins, which can be utilized for functional assays, antibody production, and further studies on its cellular mechanisms. Understanding the structure and function of SNTA1 at a molecular level will provide insights into its physiological roles and potential implications in disease, opening avenues for novel therapeutic strategies aimed at targeting syntrophin-related pathologies.
