Analytical Data
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Gene name
Insulin-1/Ins1
- Application
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Alternative Names
Ins1; Ins-1; Insulin-1 [Cleaved into: Insulin-1 B chain; Insulin-1 A chain]
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 85% as determined by SDS-PAGE.
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Uniprot
P00450
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Expression Region
807-1050aa
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Protein Length
Partial
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Molecular Weight
32.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Insulin-1 (Ins1) is a critical hormone involved in glucose metabolism and homeostasis, primarily produced by the beta cells of the pancreas. Its essential role in regulating blood sugar levels has made it a focal point in diabetes research, particularly type 1 and type 2 diabetes, where insulin production and function are impaired. Recent advances in recombinant DNA technology have enabled the production of Ins1 recombinant proteins, allowing for in-depth studies of its structure, function, and potential therapeutic applications. Research on Ins1 recombinant protein focuses on understanding the mechanisms of insulin signaling, developing new antihyperglycemic agents, and exploring ways to enhance insulin's stability and efficacy. Furthermore, Ins1’s similarities and differences compared to insulin-2 (Ins2), alongside the specific pathways influenced by each isoform, are of considerable interest, as they may contribute to developing tailored treatments for diabetes. The production and analysis of Ins1 recombinant protein have opened avenues for innovative approaches in insulin replacement therapies and regenerative medicine, potentially improving the quality of life for diabetes patients. Understanding the biochemical properties and physiological implications of Ins1 is crucial for devising more effective management strategies for glycemic control and addressing the growing prevalence of diabetes worldwide. Thus, the research surrounding Ins1 recombinant protein is not only vital for elucidating fundamental biological processes but also holds the promise of translating scientific insights into practical solutions for a significant global health challenge.
