Analytical Data
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基因名
OBSCN
- Application
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别名
BC046431; Gm878; KIAA1556; KIAA1639; OBSCN; OBSCN_HUMAN; Obscurin; Obscurin-MLCK; Obscurin-myosin light chain kinase; Obscurin-RhoGEF; OTTMUSG00000005786; UNC89
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5VST9
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表达区间
6521-6620 aa
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氨基酸序列
LGPRGPLGLFRPEPRGASPPGPQVRSLEGTSFLLREAPARPVGSAPWTQSFCTRIRRSADSGQSSFTTELSTQTVNFGTVGETVTLHICPDRDGDEAAQP
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分子量
36.63 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OBSCN (Obscurin) is a large protein that plays a critical role in the structural integrity and function of striated muscle tissues, including skeletal and cardiac muscles. It is characterized by its diverse protein-protein interaction domains, which are essential for anchoring various signaling molecules and cytoskeletal elements at the sarcomere, the fundamental unit of muscle contraction. Recent studies have highlighted the significance of OBSCN in muscle development, mechanotransduction, and pathophysiological conditions, such as cardiomyopathies and muscular dystrophies. Moreover, OBSCN has emerged as a promising candidate in regenerative medicine and gene therapy due to its involvement in muscle regeneration and repair mechanisms. Genetic mutations or dysregulation of OBSCN expression have been linked to a variety of muscular disorders, warranting further investigation into its functional mechanisms and potential therapeutic targets. Employing advanced techniques such as CRISPR-Cas9 gene editing, high-throughput sequencing, and structural biology, researchers are striving to elucidate the multifaceted roles of OBSCN in muscle physiology and pathology, with the ultimate goal of developing innovative strategies for diagnosing and treating muscle-related diseases.
