Analytical Data
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Gene name
NR2E1
- Application
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Alternative Names
Nuclear receptor subfamily 2 group E member 1. Nuclear receptor TLX. Protein tailless homolog. Tll. hTll
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y466
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Expression Region
1-385 aa
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AA Sequence
MSKPAGSTSRILDIPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRACRLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTAVTQLEPHGLELAAVSTTPERQTLVSLAQPTPKYPHEVNGTPMYLYEVATESVCESAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSGMNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRSFRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTIGNVPITRLLSDMYKSSDI
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Molecular Weight
69 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NR2E1, also known as the equivalent of the nuclear receptor subfamily 2 group E member 1, plays a critical role in the development and function of various biological systems, particularly in the central nervous system and visual system. It is involved in the regulation of gene expression that governs neuronal differentiation and retinal development. Mutations in the NR2E1 gene have been linked to several neurological disorders and retinal diseases, making it a focal point of research for understanding the underlying mechanisms of these conditions. The study of NR2E1 recombinant proteins has gained traction as scientists aim to elucidate its functional characteristics and interaction with other cellular components. By producing NR2E1 as a recombinant protein, researchers can investigate its structural properties, binding affinities, and regulatory mechanisms in a controlled environment. This knowledge is essential for developing potential therapeutic strategies targeting NR2E1-related pathologies, including gene therapy and small molecule interventions. Furthermore, recombinant NR2E1 can serve as a valuable tool for screening compounds that may influence its activity, thereby advancing drug discovery efforts aimed at combating disorders associated with NR2E1 dysfunction. Overall, the research surrounding NR2E1 recombinant proteins not only sheds light on its biological significance but also paves the way for innovative approaches to treating related diseases.
