Analytical Data
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Gene name
NPPB
- Application
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Alternative Names
NPPB；Natriuretic peptides B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P16860
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Expression Region
37-71aa
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AA Sequence
DLETSGLQEQRNHLQGKLSELQVEQTSLEPLQESP
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Molecular Weight
31.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NPPB, or Natriuretic Peptide B, is a member of the natriuretic peptide family, which plays a crucial role in regulating cardiovascular homeostasis, fluid balance, and blood pressure. Its synthesis and secretion are primarily facilitated by the heart in response to increased cardiac workload and pressure overload. Research on NPPB has gained significant momentum due to its potential implications in various cardiovascular diseases and conditions such as heart failure, hypertension, and atrial fibrillation. The recombinant form of NPPB has become a focal point for therapeutic exploration, as it offers promise in symptom alleviation and improving hemodynamics in patients with cardiac dysfunction. Studies investigating the biological effects of NPPB highlight its natriuretic, diuretic, and vasodilatory properties, which contribute to the regulation of blood volume and systemic vascular resistance. The production of recombinant NPPB allows for controlled studies to elucidate its molecular mechanisms, pharmacokinetics, and potential side effects in clinical settings. Moreover, the exploration of NPPB as a biomarker for heart failure and other cardiac conditions underscores its relevance in diagnostics and treatment strategies. With ongoing advancements in protein engineering and biotechnological methods, the future of NPPB research holds promise for the development of innovative therapeutic approaches aimed at improving patient outcomes in cardiovascular health.
