Analytical Data
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Gene name
MEF2BNB
- Application
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Alternative Names
MEF2B neighbor gene protein; mef2bnb; MF2NB_HUMAN; Protein MEF2BNB
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96FH0
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Expression Region
1-119aa
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AA Sequence
MEEPEMQLKG KKVTDKFTES VYVLANEPSV ALYRLQEHVR RSLPELAQHK ADMQRWEEQS QGAIYTVEYA CSAVKNLVDS SVYFRSVEGL LKQAISIRDH MNASAQGHSP EEPPPPSSA
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Molecular Weight
13,4 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The MEF2B gene, part of the myocyte enhancer factor 2 (MEF2) family, plays a crucial role in regulating gene expression during myogenesis and neuronal development. Recent studies have highlighted its involvement in various cellular processes, including differentiation, apoptosis, and stress responses, making it a significant focus in understanding muscle and neuronal pathologies. The MEF2B protein is known to undergo post-translational modifications that can influence its activity and stability, contributing to the dynamic regulation of gene expression. Research has revealed that mutations in MEF2B are associated with several disorders, including cardiomyopathies and neurodevelopmental disorders, indicating its importance in both muscle and brain function. To further investigate the functional mechanisms of MEF2B and develop therapeutic strategies, researchers have begun to focus on the production of recombinant MEF2B proteins. By utilizing various expression systems, scientists aim to create high-purity MEF2B variants for biochemical and structural studies. This includes examining how different post-translational modifications affect the protein's interaction with other cellular factors, as well as its role in transcriptional regulation. The development of recombinant MEF2B proteins can facilitate drug discovery, biomarker identification, and the design of novel interventions for diseases linked to MEF2B dysregulation, thus holding promise for advancing our understanding of its biological functions and therapeutic potential in related disorders.
