Analytical Data
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Gene name
NHEJ1
- Application
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Alternative Names
NHEJ1;XLF;Non-homologous end-joining factor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H9Q4
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Expression Region
1-224aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEELEQG LLMQPWAWLQ LAENSLLAKV FITKQGYALL VSDLQQVWHE QVDTSVVSQR AKELNKRLTA PPAAFLCHLD NLLRPLLKDA AHPSEATFSC DCVADALILR VRSELSGLPF YWNFHCMLAS PSLVSQHLIR PLMGMSLALQ CQVRELATLL HMKDLEIQDY QESGATLIRD RLKTEPFEEN SFLEQFMIEK LPEACSIGDG KPFVMNLQDL YMAVTTQ
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NHEJ1, also known as non-homologous end joining factor 1 (NHEJ1), plays a crucial role in the DNA repair process, particularly in the non-homologous end joining (NHEJ) pathway, which is vital for maintaining genomic stability. As a key component of the NHEJ machinery, NHEJ1 facilitates the repair of double-strand breaks (DSBs) in DNA, a type of damage that can lead to mutations, genomic instability, and cancer if not properly addressed. Research into NHEJ1 has gained momentum due to its implications in various biological processes, including cellular response to radiation and chemotherapy, as well as its potential role in therapeutic strategies for cancer treatment and gene therapy. Understanding the molecular mechanisms by which NHEJ1 operates, including its interactions with other DNA repair proteins and its regulation during the cell cycle, is critical for elucidating how cells preserve their genetic integrity in the face of DNA damage. Additionally, mutations or dysregulation of NHEJ1 have been linked to certain cancers, making it a potential biomarker for tumorigenesis and a target for innovative therapeutic approaches. As researchers delve deeper into the structural and functional characteristics of NHEJ1, the findings could pave the way for new strategies to enhance DNA repair processes, thereby improving the efficacy of cancer treatments and the development of gene editing technologies.
