Analytical Data
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Gene name
ABCD3
- Application
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Alternative Names
ABCD3；PMP70；PXMP1；ATP-binding cassette sub-family D member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P28288
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Expression Region
1-659aa
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AA Sequence
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
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Molecular Weight
81.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ABCD3, a member of the ATP-binding cassette (ABC) transporter family, has garnered significant attention in biomedical research due to its crucial role in intracellular fatty acid metabolism and peroxisomal biogenesis. This protein facilitates the transport of various lipids and peroxisomal metabolites across membranes, which is essential for maintaining cellular lipid homeostasis and overall cellular function. Dysregulation of ABCD3 has been implicated in various metabolic disorders, including peroxisomal biogenesis disorders and certain neurodegenerative diseases. Researchers have increasingly focused on the structural and functional analysis of ABCD3 to understand its transport mechanisms and regulatory pathways. Moreover, the development of recombinant ABCD3 proteins allows for advanced studies of its biochemical properties, enabling the exploration of potential therapeutic strategies to address conditions arising from its dysfunction. Understanding how ABCD3 operates at a molecular level can provide insights into its contributions to metabolic diseases, potentially leading to targeted treatments and interventions. As the field of lipidology and metabolic research expands, ABCD3 remains a pivotal focus area for uncovering the complexities of lipid transport and metabolism within the cell.
