Analytical Data
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Gene name
LMOD1
- Application
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Alternative Names
1D; 64 kDa autoantigen 1D; 64 kDa autoantigen 1D3; 64 kDa autoantigen D1; 9530015K06Rik; D1; Leiomodin; Leiomodin-1; Lmod1; LMOD1_HUMAN; muscle form; SM LMOD; SM-Lmod; SMLMOD; Smooth muscle leiomodin; Thyroid associated ophthalmopathy autoantigen ; Thyroid-associated ophthalmopathy autoantigen
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P29536
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Expression Region
1-600aa
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AA Sequence
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LMOD1 (Leiomodin 1) is a member of the tropomyosin-associated protein family, primarily expressed in striated muscle tissues. It plays a crucial role in actin filament stabilization and the regulation of muscle contraction. Research into LMOD1 has gained momentum due to its potential implications in muscle-related diseases and disorders, such as congenital myopathies and cardiomyopathies. Studies have shown that mutations in the LMOD1 gene can lead to abnormal muscle structure and function, highlighting its importance in maintaining muscle integrity. Additionally, LMOD1's interaction with tropomyosin and other actin-binding proteins positions it as a significant player in the cytoskeletal dynamics essential for muscle cell development and function. Recent advancements in recombinant protein technology have facilitated the production of LMOD1, allowing for further elucidation of its molecular mechanisms and interactions. Understanding LMOD1's structure and function can provide valuable insights into the pathophysiology of muscle diseases and pave the way for potential therapeutic strategies targeting LMOD1 or its pathways. Thus, LMOD1 recombinant protein research is not only pivotal in foundational biology but also offers prospects for clinical applications in regenerative medicine and muscle health.
