Analytical Data
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基因名
TBX5
- Application
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别名
TBX5；T-box transcription factor TBX5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99593
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表达区间
1-518aa
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氨基酸序列
MADADEGFGLAHTPLEPDAKDLPCDSKPESALGAPSKSPSSPQAAFTQQG MEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKY ILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMR QLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTA FCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDMELHRMSRM QSKEYPVVPRSTVRQKVASNHSPFSSESRALSTSSNLGSQYQCENGVSGP SQDLLPPPNPYPLPQEHSQIYHCTKRKEEECSTTDHPYKKPYMETSPSEE DSFYRSSYPQQQGLGASYRTESAQRQACMYASSAPPSEPVPSLEDISCNT WPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQL GEGMFQHQTSVAHQPVVRQCGPQTGLQSPGTLQPPEFLYSHGVPRTLSPH QYHSVHGVGMVPEWSDNS
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分子量
84 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBX5 is a T-box transcription factor critically involved in the regulation of developmental processes, particularly in heart and limb formation. Mutations in the TBX5 gene are linked to various congenital disorders, such as Holt-Oram syndrome, which is characterized by skeletal malformations and congenital heart defects. Research into TBX5 recombinant proteins aims to elucidate the molecular mechanisms by which TBX5 influences gene expression and developmental pathways. Understanding the structure-function relationship of TBX5 through recombinant protein studies can provide insights into its role in embryogenesis and tissue differentiation. Furthermore, these studies facilitate the exploration of TBX5 as a potential therapeutic target for regenerative medicine and genetic disorders. As the field of molecular biology advances, the generation and characterization of TBX5 recombinant proteins can lead to breakthroughs in understanding how T-box transcription factors modulate cellular processes and contribute to various pathologies. This research can also pave the way for innovative strategies in gene therapy, where restoring or modifying TBX5 activity might offer novel treatment avenues for related congenital anomalies. Overall, TBX5 recombinant protein studies hold significant promise for both fundamental biology and clinical applications, making them a focal point for ongoing research in the field of developmental genetics.
