Analytical Data
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基因名
KIR2DS5
- Application
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别名
KIR2DS5; CD158G; NKAT9Killer cell immunoglobulin-like receptor 2DS5; CD158 antigen-like family member G; MHC class I NK cell receptor; Natural killer-associated transcript 9; NKAT-9; CD antigen CD158g
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q14953
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表达区间
1-304aa
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氨基酸序列
MSLMVISMACVAFFLLQGAWPHEGFRRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGTFNHTLRLIGEHIDGVSKGNFSIGRMTQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNRTFQADFPLDPATHGGTYRCFGSFRDSPYEWSKSSDPLLVSVTGNSSNSWPSPTEPSSETGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSNKKNASVMDQGPAGNRTVNREDSDEQDHQEVSYA
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分子量
59.84 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DS5 is a member of the Killer Immunoglobulin-like Receptor (KIR) family, which plays a crucial role in the regulation of natural killer (NK) cell activity and immune responses. KIR receptors are expressed on the surface of NK cells and are involved in recognizing and responding to infected or transformed cells. KIR2DS5 is specifically categorized as an activating receptor, meaning it can enhance NK cell cytotoxicity upon engagement with its ligand. Research into KIR2DS5 is particularly significant due to its implications in various diseases, including viral infections, autoimmune disorders, and cancer. The protein's ability to promote NK cell activation raises questions about its potential therapeutic applications, such as in immunotherapy, where harnessing the immune system to target tumors is key. Despite the importance of KIR2DS5, understanding its structural and functional characteristics remains limited, necessitating further investigations. Recombinant techniques allow for the expression and purification of KIR2DS5, facilitating studies on its ligand interactions and signaling pathways. This research could provide insights into the delicate balance between immune activation and tolerance, which is critical for developing novel therapeutic strategies that could enhance immune responses against malignancies and infectious agents while minimizing the risk of autoimmunity. As such, KIR2DS5 presents a valuable target for further investigation within the fields of immunology and therapeutic development.
