Analytical Data
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基因名
CRYbB2
- Application
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别名
CRYbB2；CRYB2；CRYB2A；Beta-crystallin B2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43320
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表达区间
1-205aa
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氨基酸序列
MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSN
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分子量
23.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CRYbB2, a member of the cryopyrin/Pyrin family of proteins, is an intriguing target of research due to its essential role in regulating innate immune responses and maintaining cellular homeostasis. This protein functions primarily as a regulator of the NLRP3 inflammasome, a crucial component of the immune system that activates the production of pro-inflammatory cytokines in response to various pathogens and stress stimuli. Dysregulation of CRYbB2 has been implicated in several autoimmune and inflammatory diseases, making it a potential therapeutic target. Recent studies have focused on recombinant forms of CRYbB2 to elucidate its structural and functional properties, facilitating a deeper understanding of its mechanisms in immune modulation. By producing CRYbB2 in a recombinant manner, researchers aim to explore its interactions with other cellular components and identify novel pathways involved in inflammation and immune responses. The research surrounding CRYbB2 is essential not only for the advancement of immunology but also for developing innovative strategies to combat diseases characterized by inappropriate immune activation. Understanding the precise molecular mechanisms by which CRYbB2 influences inflammatory pathways could pave the way for targeted therapies and improve the management of related health conditions.
