Analytical Data
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基因名
IL-1α
- Application
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01583
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表达区间
113-271aa
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氨基酸序列
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
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分子量
18.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-1 alpha (IL-1α) is a pro-inflammatory cytokine that plays a crucial role in the immune response, inflammation, and various physiological processes. It is primarily produced by activated macrophages and is essential for host defense mechanisms against infections and tissue injury. Research on IL-1α has gained prominence due to its involvement in a variety of pathological conditions, including autoimmune diseases, chronic inflammatory diseases, and certain types of cancer. Dysregulation of IL-1α production and signaling can lead to excessive inflammation and tissue damage, making it a target for therapeutic intervention. The recombinant form of IL-1α has been developed for use in both basic research and potential clinical applications. In laboratory settings, recombinant IL-1α is utilized to study its biological effects on immune cells, its role in inflammatory responses, and its implications in disease models. Furthermore, understanding the functional mechanisms of IL-1α can aid in the development of novel therapies, including IL-1 receptor antagonists, which are currently employed to treat various inflammatory disorders. Overall, the study of IL-1α recombinant protein is vital for advancing our knowledge of immune regulation and for identifying new avenues for therapeutic intervention in inflammation-related diseases.
