Analytical Data
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Gene name
PMT2
- Application
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Alternative Names
PMT2；Dolichyl-phosphate-mannose--Protein mannosyltransferase 2
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Species
E.coli
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31382
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Expression Region
311-609aa
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AA Sequence
LLSHSGTGDANMPSLFQARLVGSDVGQGPRDIALGSSVVSIKNQALGGSLLHSHIQTYPDGSNQQQVTCYGYKDANNEWFFNRERGLPSWSENETDIEYLKPGTSYRLVHKSTGRNLHTHPVAAPVSKTQWEVSGYGDNVVGDNKDNWVIEIMDQRGDEDPEKLHTLTTSFRIKNLEMGCYLAQTGNSLPEWGFRQQEVVCMKNPFKRDKRTWWNIETHENERLPPRPEDFQYPKTNFLKDFIHLNLAMMATNNALVPDPDKFDYLASSAWQWPTLNVGLRLCGWGDDNPKYFLLGTPA
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Molecular Weight
38.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PMT2, or Protein Methyltransferase 2, is a key player in the post-translational modification landscape, particularly within the context of cellular signaling and gene regulation. This enzyme is known for its role in methylating proteins, which can alter their function, stability, and interactions, thereby influencing various biological processes. Research on PMT2 has gained significant traction due to its implications in human health and disease, especially in cancer and neurodegenerative disorders. Aberrant methylation patterns mediated by PMT2 can lead to dysregulated signaling pathways, contributing to tumorigenesis and other pathologies. Understanding the structure and function of PMT2, along with its substrate specificity, is crucial for elucidating its role in cellular mechanisms. Moreover, PMT2 represents a potential therapeutic target; inhibitors of this enzyme could offer novel strategies for intervention in diseases characterized by abnormal protein methylation. Recent advances in techniques such as CRISPR/Cas9 gene editing and high-throughput proteomics have enabled researchers to dissect the biological functions and clinical relevance of PMT2 more effectively, paving the way for future studies aimed at harnessing its potential in targeted therapies and precision medicine. As the field of epigenetics continues to expand, PMT2 stands out as a pivotal molecule that bridges the gap between genetic information and functional outcomes in cells.
