Analytical Data
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基因名
SSRP1
- Application
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别名
SSRP1；FACT80；FACT complex subunit SSRP1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08945
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表达区间
1-709aa
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氨基酸序列
MAETLEFNDVYQEVKGSMNDGRLRLSRQGIIFKNSKTGKVDNIQAGELTEGIWRRVALGHGLKLLTKNGHVYKYDGFRESEFEKLSDFFKTHYRLELMEKDLCVKGWNWGTVKFGGQLLSFDIGDQPVFEIPLSNVSQCTTGKNEVTLEFHQNDDAEVSLMEVRFYVPPTQEDGVDPVEAFAQNVLSKADVIQATGDAICIFRELQCLTPRGRYDIRIYPTFLHLHGKTFDYKIPYTTVLRLFLLPHKDQRQMFFVISLDPPIKQGQTRYHFLILLFSKDEDISLTLNMNEEEVEKRFEGRLTKNMSGSLYEMVSRVMKALVNRKITVPGNFQGHSGAQCITCSYKASSGLLYPLERGFIYVHKPPVHIRFDEISFVNFARGTTTTRSFDFEIETKQGTQYTFSSIEREEYGKLFDFVNAKKLNIKNRGLKEGMNPSYDEYADSDEDQHDAYLERMKEEGKIREENANDSSDDSGEETDESFNPGEEEEDVAEEFDSNASASSSSNEGDSDRDEKKRKQLKKAKMAKDRKSRKKPVEVKKGKDPNAPKRPMSAYMLWLNASREKIKSDHPGISITDLSKKAGEIWKGMSKEKKEEWDRKAEDARRDYEKAMKEYEGGRGESSKRDKSKKKKKVKVKMEKKSTPSRGSSSKSSSRQLSESFKSKEFVSSDESSSGENKSKKKRRRSEDSEEEELASTPPSSEDSASGSDE
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分子量
81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SSRP1 (Structural Maintenance of Chromosomes Flexible Domain-containing Protein 1) has emerged as a significant focus in molecular biology due to its critical role in chromatin remodeling and transcription regulation. As a core component of the FACT (Facilitates Chromatin Transcription) complex, SSRP1 is involved in the modification of histone-DNA interactions, facilitating the passage of RNA polymerase II during transcription. This function is particularly important for ensuring proper gene expression and is implicated in various cellular processes, including DNA repair and replication. Dysregulation of SSRP1 has been linked to several diseases, including cancer, where altered chromatin dynamics can lead to aberrant gene expression patterns. Recent studies have harnessed recombinant protein technologies to produce and analyze SSRP1, enabling researchers to explore its structural properties, binding mechanisms, and functional implications in the context of chromatin dynamics. By developing SSRP1 as a recombinant protein, scientists are not only improving our understanding of its biological roles but also potentially identifying novel therapeutic targets for conditions related to chromatin instability. This research lays the groundwork for further investigations into the molecular mechanisms underpinning SSRP1's action in cells and its broader implications in health and disease. Additionally, the use of SSRP1 in various experimental setups opens avenues for investigating protein-protein interactions within the FACT complex and other chromatin-associated factors, ultimately contributing to a more comprehensive understanding of gene regulation at the chromatin level.
