Analytical Data
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Gene name
GPR22
- Application
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Alternative Names
GPR22; G-protein coupled receptor 22
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99680
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Expression Region
1-433aa
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AA Sequence
MCFSPILEINMQSESNITVRDDIDDINTNMYQPLSYPLSFQVSLTGFLMLEIVLGLGSNLTVLVLYCMKSNLINSVSNIITMNLHVLDVIICVGCIPLTIVILLLSLESNTALICCFHEACVSFASVSTAINVFAITLDRYDISVKPANRILTMGRAVMLMISIWIFSFFSFLIPFIEVNFFSLQSGNTWENKTLLCVSTNEYYTELGMYYHLLVQIPIFFFTVVVMLITYTKILQALNIRIGTRFSTGQKKKARKKKTISLTTQHEATDMSQSSGGRNVVFGVRTSVSVIIALRRAVKRHRERRERQKRVFRMSLLIISTFLLCWTPISVLNTTILCLGPSDLLVKLRLCFLVMAYGTTIFHPLLYAFTRQKFQKVLKSKMKKRVVSIVEADPLPNNAVIHNSWIDPKRNKKITFEDSEIREKCLVPQVVTD
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Molecular Weight
49.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR22 is a member of the G protein-coupled receptor (GPCR) family, known for its role in various physiological processes and potential implications in disease states. Despite being an orphan receptor, meaning its endogenous ligand is unidentified, research has suggested GPR22's involvement in modulating central nervous system functions, making it a subject of interest for neuropharmacology. Studies indicate that GPR22 expression is notably present in the brain, particularly in regions associated with mood regulation and cognitive function, hinting at its potential role in neuropsychiatric disorders. The exploration of GPR22 recombinant proteins has become essential for elucidating its signaling mechanisms and understanding ligand-receptor interactions. Characterizing this receptor through recombinant protein studies allows researchers to investigate its pharmacological profiles and potential therapeutic targets, particularly in mood disorders and neurodegenerative conditions. Advances in protein expression systems enable the production of GPR22 in sufficient quantities for high-throughput screening and structure-function analysis. This research could pave the way for developing novel drug candidates aimed at modulating GPR22 activity, thereby exploring new avenues for treating complex brain disorders. Overall, the study of GPR22 recombinant proteins is crucial for unlocking the therapeutic potential of this enigmatic receptor and contributing to the broader field of GPCR research.
