Analytical Data
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基因名
DRB5
- Application
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别名
DRB5；HLA class II histocompatibility antigen. DR beta 5 chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q30154
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表达区间
1-266aa
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氨基酸序列
MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLLFLGAGLFIYFKNQKGHSGLHPTGLVS
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分子量
30.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DRB5, a member of the major histocompatibility complex (MHC) class II family, plays a crucial role in the immune response by presenting peptides derived from extracellular proteins to CD4+ T cells. This process is essential for the activation of the adaptive immune system, influencing various immune-mediated diseases and responses. Research on recombinant DRB5 proteins has gained significant attention due to their potential applications in vaccine development, immune therapy, and understanding autoimmune disorders. The recombinant expression of DRB5 allows for the study of its structure and function, including its peptide-binding characteristics and interactions with T cell receptors. By elucidating these mechanisms, scientists aim to enhance our understanding of how specific peptide sequences can modulate immune responses, paving the way for the design of targeted therapies. Furthermore, studying DRB5 variants can shed light on population-specific immune responses and susceptibility to diseases. The production of DRB5 as a recombinant protein also enables the development of diagnostic tools and therapeutic agents, emphasizing its relevance in both fundamental immunology and clinical applications. Thus, the investigation of DRB5 recombinant proteins is crucial for advancing immunological knowledge and improving disease management strategies.
