Analytical Data
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Gene name
DRB5
- Application
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Alternative Names
DRB5；HLA class II histocompatibility antigen. DR beta 5 chain
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q30154
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Expression Region
1-266aa
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AA Sequence
MVCLKLPGGSYMAKLTVTLMVLSSPLALAGDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFDSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRHNYGVGESFTVQRRVEPKVTVYPARTQTLQHHNLLVCSVNGFYPGSIEVRWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRAQSESAQSKMLSGVGGFVLGLLFLGAGLFIYFKNQKGHSGLHPTGLVS
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Molecular Weight
30.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DRB5, a member of the major histocompatibility complex (MHC) class II family, plays a crucial role in the immune response by presenting peptides derived from extracellular proteins to CD4+ T cells. This process is essential for the activation of the adaptive immune system, influencing various immune-mediated diseases and responses. Research on recombinant DRB5 proteins has gained significant attention due to their potential applications in vaccine development, immune therapy, and understanding autoimmune disorders. The recombinant expression of DRB5 allows for the study of its structure and function, including its peptide-binding characteristics and interactions with T cell receptors. By elucidating these mechanisms, scientists aim to enhance our understanding of how specific peptide sequences can modulate immune responses, paving the way for the design of targeted therapies. Furthermore, studying DRB5 variants can shed light on population-specific immune responses and susceptibility to diseases. The production of DRB5 as a recombinant protein also enables the development of diagnostic tools and therapeutic agents, emphasizing its relevance in both fundamental immunology and clinical applications. Thus, the investigation of DRB5 recombinant proteins is crucial for advancing immunological knowledge and improving disease management strategies.
