Analytical Data
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基因名
ETS2
- Application
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别名
ETS2;Protein C-ets-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P15036
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表达区间
1-469aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED
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分子量
55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of ETS2, an ETS (E26 transcription factor) family transcription factor, has garnered significant attention due to its pivotal role in regulating gene expression during development, differentiation, and cellular response to environmental stimuli. ETS2 is implicated in various biological processes, including oncogenesis, cellular proliferation, and apoptosis. Dysregulation of ETS2 has been associated with several cancers, making it a crucial target for understanding tumorigenesis and developing therapeutic strategies. Research has revealed that ETS2 functions not only as a transcriptional activator but also exhibits repressive characteristics under certain conditions, thereby contributing to a complex regulatory network. Moreover, the ability of ETS2 to interact with other transcription factors, co-factors, and chromatin remodeling complexes highlights its versatility and significance in gene regulation. The investigation of recombinant ETS2 proteins has advanced our understanding of its structural and functional properties, paving the way for potential applications in gene therapy and personalized medicine. Through molecular cloning and expression studies, researchers are exploring the mechanisms by which ETS2 influences gene networks, aiming to elucidate the pathways involved in its oncogenic functions. Understanding the multifaceted roles of ETS2 in normal and pathological states is critical for leveraging its potential in clinical applications, such as targeted cancer therapies and regenerative medicine.
