Analytical Data
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基因名
AZIN1
- Application
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别名
AZIN1；OAZI；OAZIN；Antizyme inhibitor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14977
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表达区间
1-448aa
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氨基酸序列
MKGFIDDANY SVGLLDEGTN LGNVIDNYVY EHTLTGKNAF FVGDLGKIVK KHSQWQNVVA QIKPFYTVKC NSAPAVLEIL AALGTGFACS SKNEMALVQE LGVPPENIIY ISPCKQVSQI KYAAKVGVNI LTCDNEIELK KIARNHPNAK VLLHIATEDN IGGEEGNMKF GTTLKNCRHL LECAKELDVQ IIGVKFHVSS ACKESQVYVH ALSDARCVFD MAGEIGFTMN MLDIGGGFTG TEFQLEEVNH VISPLLDIYF PEGSGVKIIS EPGSYYVSSA FTLAVNIIAK KVVENDKFPS GVEKTGSDEP AFMYYMNDGV YGSFASKLSE DLNTIPEVHK KYKEDEPLFT SSLWGPSCDE LDQIVESCLL PELNVGDWLI FDNMGADSFH EPSAFNDFQR PAIYYMMSFS DWYEMQDAGI TSDSMMKNFF FVPSCIQLSQ EDSFSAEA
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分子量
49.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AZIN1 (antizyme inhibitor 1) is a key regulatory protein involved in polyamine metabolism, playing a critical role in cellular growth and differentiation. Its primary function is to inhibit the activity of antizymes, which are proteins that regulate the polyamine synthesis pathway by negatively modulating ornithine decarboxylase (ODC) activity. Dysregulation of AZIN1 has been implicated in various pathological conditions, including cancer, where altered polyamine levels contribute to increased cell proliferation and tumor progression. Recent studies have focused on the characterization of recombinant AZIN1 protein to unravel its structural and functional properties, as well as its interactions with antizymes and ODC. Understanding the molecular mechanisms governing AZIN1 activity may shed light on its role in diseases and could lead to potential therapeutic targets. Consequently, research into recombinant AZIN1 serves as a promising avenue for developing strategies to manipulate polyamine levels in disease contexts, thereby highlighting its significance in cellular homeostasis and disease management.
