Analytical Data
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基因名
KAE1
- Application
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别名
KAE1；tRNA N6-adenosine threonylcarbamoyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPF4
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表达区间
1-335aa
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氨基酸序列
MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
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分子量
63.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KAE1 (KAT6-interacting protein 1) is a member of the KAT6 family of histone acetyltransferases, which play critical roles in regulating gene expression through chromatin remodeling. Research has highlighted the importance of KAE1 in various biological processes, including cell differentiation, proliferation, and response to stress. Abnormalities in KAE1 expression and function have been linked to several diseases, particularly cancer, where altered acetylation patterns can lead to oncogene activation or tumor suppressor gene repression. To better understand the mechanisms by which KAE1 influences these processes, scientists are focusing on the characterization and functional analysis of recombinant KAE1 proteins. This approach facilitates the elucidation of KAE1's catalytic activity, interactions with other essential proteins, and its role in histone modification pathways. Additionally, studying the recombinant protein allows researchers to explore potential therapeutic targets for diseases associated with dysregulated KAE1 function, thereby contributing to the development of novel strategies in cancer treatment and other disorders.
