Analytical Data
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基因名
GAN
- Application
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别名
GAN；GAN1；KLHL16；Gigaxonin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H2C0
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表达区间
1-597aa
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氨基酸序列
MAEGSAVSDP QHAARLLRAL SSFREESRFC DAHLVLDGEE IPVQKNILAA ASPYIRTKLN YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED TIQDVVQAAD LLLLTDLKTL CCEFLEGCIA AENCIGIRDF ALHYCLHHVH YLATEYLETH FRDVSSTEEF LELSPQKLKE VISLEKLNVG NERYVFEAVI RWIAHDTEIR KVHMKDVMSA LWVSGLDSSY LREQMLNEPL VREIVKECSN IPLSQPQQGE AMLANFKPRG YSECIVTVGG EERVSRKPTA AMRCMCPLYD PNRQLWIELA PLSMPRINHG VLSAEGFLFV FGGQDENKQT LSSGEKYDPD ANTWTALPPM NEARHNFGIV EIDGMLYILG GEDGEKELIS MECYDIYSKT WTKQPDLTMV RKIGCYAAMK KKIYAMGGGS YGKLFESVEC YDPRTQQWTA ICPLKERRFG AVACGVAMEL YVFGGVRSRE DAQGSEMVTC KSEFYHDEFK RWIYLNDQNL CIPASSSFVY GAVPIGASIY VIGDLDTGTN YDYVREFKRS TGTWHHTKPL LPSDLRRTGC AALRIANCKL FRLQLQQGLF RIRVHSP
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分子量
67.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on GAN (Guanosine-5'-triphosphate)-binding protein reconstitution has gained significant attention due to its pivotal role in various cellular processes, including signal transduction, cellular motility, and metabolism. GAN proteins are part of a larger family of GTPases, which function as molecular switches that alternate between active (GTP-bound) and inactive (GDP-bound) states. The proper functioning of these proteins is crucial for maintaining cellular homeostasis and responding to environmental stimuli. Dysregulation of GAN proteins has been implicated in several diseases, including cancer and neurodegenerative disorders, underscoring the importance of understanding their mechanisms. Reconstituting GAN proteins in vitro allows researchers to dissect their functional dynamics and interactions with other cellular components in a controlled environment. This approach not only aids in elucidating the fundamental principles of GTPase activity but also paves the way for therapeutic interventions targeting aberrant GAN signaling pathways. By utilizing techniques such as protein engineering and cellular assays, scientists can explore the various conformational states of GAN proteins and identify key regulatory elements that govern their activity. Overall, the study of GAN protein reconstitution serves as a vital avenue for advancing our knowledge of cellular signaling networks and developing potential strategies for disease treatment.
