Analytical Data
-
Gene name
Cenpa
- Application
-
Alternative Names
Cenpa；Histone H3-like centromeric Protein A
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P49450
-
Expression Region
1-114aa
-
AA Sequence
MGPRRRSRKP EAPRRRSPSP TPTPGPSRRG PSLGASSHQH SRRRQGWLKE IRKLQKSTHL LIRKLPFSRL AAEAFLVHLF EDAYLLTLHA GRVTLFPKDV QLARRIRGLE EGLG
-
Molecular Weight
16 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Cenpa, a critical histone variant, plays a pivotal role in the assembly and function of the centromere, which is essential for accurate chromosome segregation during cell division. The study of Cenpa and its recombinant forms has gained significant attention due to its implications in genomic stability and the potential development of cancer therapies. Research has shown that Cenpa is involved in the formation of the kinetochore, a structure that mediates the attachment of chromosomes to the spindle apparatus. Abnormalities in Cenpa expression or function can lead to chromosomal instability, a hallmark of many cancers. Consequently, understanding the molecular mechanisms underlying Cenpa regulation and its interactions with other centromeric proteins could provide insights into the etiology of cancer and other genetic disorders. The generation of recombinant Cenpa proteins allows researchers to study their biochemical properties, interactions, and functional dynamics in vitro and in cellular models. Such studies facilitate the exploration of Cenpa's role in centromere architecture, epigenetic regulation, and the broader implications of chromosomal organization in health and disease. The ongoing research on Cenpa not only contributes to fundamental biology but also holds promise for therapeutic advancements by targeting centromere-related pathways in cancer treatment. This multifaceted approach underlines the importance of Cenpa as a focal point in genomic research, offering potential avenues for future investigations and applications in medicine.
