Analytical Data
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Gene name
DDC
- Application
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Alternative Names
DDC；AADC;Aromatic-L-amino-acid decarboxylase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20711
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Expression Region
1-480aa
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AA Sequence
MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DDC (Dipeptidyl Peptidase IV) is an important enzyme involved in various physiological processes, including glucose metabolism and immune regulation. Its dysfunction has been linked to several diseases, such as diabetes, cancer, and metabolic disorders. The study of DDC recombinants is critical to understanding its structure-function relationships, facilitating the development of therapeutic agents and diagnostic tools. The recombinant production of DDC allows for the examination of its enzymatic activity, stability, and interactions with potential inhibitors or substrates. This is essential in identifying specific roles of DDC in disease contexts and can aid in drug discovery processes. Moreover, characterizing DDC through recombinant techniques helps elucidate post-translational modifications and the influence of its conformation on biophysical properties. As researchers continue to explore DDC’s functionality, recombinant techniques provide a valuable approach to unraveling the complexities of this enzyme, ultimately contributing to advancements in targeted therapies and personalized medicine. Efforts in this area have shown promise in enhancing our understanding of DDC-related pathways and developing novel interventions for related diseases.
