Analytical Data
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Gene name
DGCR6
- Application
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Alternative Names
DGCR6;Protein DGCR6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14129
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Expression Region
1-220aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMERYAGA LEEVADGARQ QERHYQLLSA LQSLVKELPS SFQQRLSYTT LSDLALALLD GTVFEIVQGL LEIQHLTEKS LYNQRLRLQN EHRVLRQALR QKHQEAQQAC RPHNLPVLQA AQQRELEAVE HRIREEQRAM DQKIVLELDR KVADQQSTLE KAGVAGFYVT TNPQELMLQM NLLELIRKLQ QRGCWAGKAA LGLGGPWQLP AAQCDQKGSP VPP
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DGCR6 is a gene located on chromosome 22, part of the DiGeorge syndrome critical region, which has garnered significant interest due to its potential implications in developmental abnormalities and immune response. Research on DGCR6 recombinant protein has gained momentum as it exhibits roles in cell proliferation, differentiation, and apoptosis, particularly in the context of congenital heart defects and other neurodevelopmental disorders associated with chromosome 22q11.2 deletions. Understanding the structure and function of DGCR6 can provide insights into its molecular mechanisms and its interactions with other proteins involved in critical biological pathways. The production of recombinant DGCR6 protein allows for in-depth functional assays and exploration of its biological roles, paving the way for potential therapeutic strategies aimed at ameliorating conditions linked with DGCR6 dysregulation. Moreover, studying this protein in various cellular and animal models will enable researchers to elucidate its specific contributions to pathophysiological processes related to DiGeorge syndrome and similar disorders, ultimately leading to improved diagnostic and treatment options for affected individuals.
