Analytical Data
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基因名
OLIG2
- Application
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别名
OLIG2；BHLHB1；BHLHE19；PRKCBP2；Oligodendrocyte transcription factor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13516
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表达区间
1-323aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHGNLYFQGGEFDSDASLVSSRPSSPEPDDLFL PARSKGSSGSAFTG GTVSSSTPSDCPPELSAELRGAMGSAGAHPGDKL GGSGFKSSSSSTSSSTSSAAASSTKKDKKQ MTEPELQQLRLKINSRER KRMHDLNIAMDGLREVMPYAHGPSVRKLSKIATLLLARNYILMLTN SL EEMKRLVSEIYGGHHAGFHPSACGGLAHSAPLPAATAHPAAAAHAAHHPA VHHPILPPAAAA AAAAAAAAAVSSASLPGSGLPSVGSIRPPHGLLKSP SAAAAAPLGGGGGGSGASGGFQHWGGMP CPCSMCQVPPPHHHVSAMGA GSLPRLTSDAK
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
OLIG2 is a key transcription factor that plays a crucial role in the development of the central nervous system, particularly in the specification and differentiation of oligodendrocyte precursor cells. It is known to be essential for the proper maturation of oligodendrocytes, which are responsible for the myelination of axons in the brain and spinal cord. Dysregulation of OLIG2 has been implicated in various neurological disorders, including multiple sclerosis and certain types of brain tumors, such as gliomas. Consequently, studying OLIG2 and its functions can provide insights into the mechanisms of neurodevelopment and the pathogenesis of these diseases. The production of recombinant OLIG2 protein allows researchers to investigate its structural and functional characteristics in vitro, facilitating the understanding of its binding properties, post-translational modifications, and interactions with other cellular components. This can also aid in the development of therapeutic strategies targeting OLIG2-related pathways. Overall, research on OLIG2 recombinant protein is pivotal for uncovering its contributions to neural cell biology and for exploring potential clinical applications in neurodegenerative diseases and cancer.
